Two Exciting Anti Aging Supplements
There are two really exciting anti aging supplements; TA-65 and resveratrol. We still do not fully understand how or why we age, but each day we learn more and more. Supplements like antioxidants, which combat free radicals are essential to an anti aging program, but TA-65 and resveratrol are two anti aging supplements that are more promising in their ability to delay aging and perhaps even reverse it.
One theory of aging is the Telomerase Theory of Aging. Telomeres are repeating sequences of nucleic acids that cap the ends of chromosomes. Like the little plastic caps at the end of shoelaces that protect them from unraveling, telomeres similarly protect chromosomes. Every time a cell divides telomeres become shorter. At some point telomeres become too short to protect the chromosomes and cell division is no longer possible.
TA-65 can activate an enzyme called telomerase, which can repair and replace telomeres potentially re-setting the ticking clock of aging. TA-65 is produced from the Chinese herb, Astragalus. Though, astragalus extracts can be found in health food stores, the amount of TA-65 found in the extracts is barely detectible.
TA-65 was discovered by the Geron Corporation, a leading biotechnology company and is licensed to TA Sciences for clinical use. In a double-blind placebo controlled study TA-65 was demonstrated to improve immune function, vision, male sexual performance, skin appearance, and increase energy and well-being.
Tested in humans since 2005, there have been no reported adverse effects with TA-65. There is a theoretical concern that TA-65 could stimulate growth of cancer cells, but that has not been demonstrated to occur, perhaps because of the enhancement in immune function caused by TA-65.
TA-65 is available only through physicians licensed by TA Sciences. Various programs for its use are available and currently cost $1,200 to $4,000 for a 6 month supply of TA-65. More detailed information about cost and TA Sciences licensed physicians can be found at its website.
Resveratrol and Longevity
Calorie restriction seems like the last way to improve longevity, but calorie restriction has been shown over and over in every animal studied to increase individual lifespan, perhaps because unnecessary calories places a metabolic strain on the body. Calorie restriction usually refers to consuming 30% fewer calories than one would normally consume when they are free to eat.
Calorie restriction places a “stress” on the body leading it to become more metabolically efficient, and provoking a survival response leading to improved DNA and chromosomal repair, enhanced energy use, increased cell survival, and improved response to stress. These events are triggered by activation of sirtuin genes triggered by calorie restriction.
Plants that are stressed produce molecules that also activate sirtuin genes. These molecules are called STACs for sirtuin activating compounds, and the most powerful one discovered thus far is resveratrol.
Resveratrol is a fungicide produced in high concentrations in the skins of grapes and the Chinese Knot Wood root. It’s also found in smaller amounts in peanuts and dark chocolate. Resveratrol is also present in small amounts in wine, especially red wines. Resveratrol may explain the French Paradox, or the observation that the French have lower incidences of heart disease despite consuming diet high in saturated fats.
Resveratrol is now readily available in supplement form. It is unclear what the optimal dose of resveratrol is. Many of those researching the benefits of resveratrol report taking 500 mg to 1,000 mg a day. Though there have been a few anecdotal reports of side effects in doses exceeding 500 mg a day, no significant side effects have been reported in scientific studies in doses up to 5,000 mg a day.
TA-65 and resveratrol are two anti aging supplements that get to heart of why we age.
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